BDBM445449 US10683279, Example 46a::US10988458, Example 46a::US11560368, Example 46a

SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)N2CCOCC2)-n2cnc(c2)C2CC2)n1

InChI Key InChIKey=LEQRDCNDCXHQNS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445449   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM445449(US10683279, Example 46a | US10988458, Example 46a ...)
Affinity DataIC50:  5.5nMAssay Description:ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM445449(US10683279, Example 46a | US10988458, Example 46a ...)
Affinity DataIC50:  5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM445449(US10683279, Example 46a | US10988458, Example 46a ...)
Affinity DataIC50:  5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE™ Assay System was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent