BDBM446004 US10669246, Example 55::US10968188, Example 55

SMILES COc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1

InChI Key InChIKey=RYDXEOCUWPNWBT-PWSUYJOCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446004   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM446004(US10669246, Example 55 | US10968188, Example 55)
Affinity DataIC50:  5.90nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM446004(US10669246, Example 55 | US10968188, Example 55)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of recombinant human His-tagged c-Abl kinase assessed as luminescence incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM446004(US10669246, Example 55 | US10968188, Example 55)
Affinity DataIC50:  5.90nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo™ Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent