BDBM446016 US10669246, Example 67::US10968188, Example 67

SMILES Cc1cc(ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C(F)(F)F

InChI Key InChIKey=PTDKKYOVXZBBKS-PWSUYJOCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446016   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM446016(US10669246, Example 67 | US10968188, Example 67)
Affinity DataIC50:  455nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo™ Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM446016(US10669246, Example 67 | US10968188, Example 67)
Affinity DataIC50:  455nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent