BDBM446077 N-(2-{4-[(3,5-difluorophenyl)methoxy]piperidin-1-yl}-2-(4- methyl-1,3-thiazol-5-yl)ethyl)quinoline-5-carboxamide::US10669267, Compound 17

SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cc(F)cc(F)c1

InChI Key InChIKey=NQHIHSJMZCPHKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446077   

TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Axxam

US Patent
LigandPNGBDBM446077(N-(2-{4-[(3,5-difluorophenyl)methoxy]piperidin-1-y...)
Affinity DataIC50:  432nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM446077(N-(2-{4-[(3,5-difluorophenyl)methoxy]piperidin-1-y...)
Affinity DataIC50:  32.9nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent