BDBM447333 (2S,4R)—N-(1-cyanocyclopropyl)-4-(2,4-di(1H-1,2,4-triazol-1-yl)phenylsulfonyl)-1-(1-(trifluoromethyl)cyclopropanecarbonyl)pyrrolidine-2-carboxamide::US10689339, Example 11

SMILES FC(F)(F)C1(CC1)C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccc(cc1-n1cncn1)-n1cncn1

InChI Key InChIKey=KFIAJQCAFURTIY-AEFFLSMTSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447333   

TargetCathepsin S(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM447333((2S,4R)—N-(1-cyanocyclopropyl)-4-(2,4-di(1H-1,2,4-...)
Affinity DataIC50:  12.6nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent