BDBM448431 1-({6-[(1R,5S,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-methylpyridin-3-yl}methyl)-N-[(6R)- 3-methyl-1H,4H,5H,6H-cyclopenta[c]pyrazol-6-yl]-1H-pyrazole-4-carboxamide::US10695334, Example 94

SMILES Cc1c2CC[C@@H](NC(=O)c3cnn(Cc4ccc(nc4C)N4C[C@H]5[C@@H](CO)[C@H]5C4)c3)c2nn1COCC[Si](C)(C)C

InChI Key InChIKey=JIMFFGPZQNHMHY-HVWQDESWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 448431   

TargetThymidine kinase, cytosolic(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448431(1-({6-[(1R,5S,6R)-6-(hydroxymethyl)-3-azabicyclo[3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent