BDBM448751 (R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)ethyl)amino)-6- fluoropyrimidin-4-yl)-4-((S)-1- fluoroethyl)oxazolidin-2-one::US10696665, Example 19

SMILES C[C@H](F)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(=O)C=C)cc2)n1

InChI Key InChIKey=QDDYYGMEQZHXSV-ABSDTBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448751   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM448751((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50:  35.3nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM448751((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50:  50.1nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent