BDBM448973 4-(1-Ethyl-5-fluoro-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazolel-7-yl)-5-fluoro-N-(5-(1-methylpiperidine-4-yl)pyridin-2-yl)pyrimidin-2-amine::US10696678, Example 68

SMILES CCC1CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F

InChI Key InChIKey=OTWAFVLIHBNVCX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448973   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448973(4-(1-Ethyl-5-fluoro-2,3-dihydro-1H-benzo[d]pyrrolo...)
Affinity DataIC50:  6.00E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448973(4-(1-Ethyl-5-fluoro-2,3-dihydro-1H-benzo[d]pyrrolo...)
Affinity DataIC50:  9.00E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent