BDBM449991 US10703755, Example 109
SMILES CCOc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc(CN4C[C@@H]5C[C@H]4CN5C)cc3)c2n1
InChI Key InChIKey=RIJUCCOLHSAZPO-GOTSBHOMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 449991
Affinity DataIC50: 15nMAssay Description:Antagonist activity at R848 stimulated TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with comp...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...More data for this Ligand-Target Pair