BDBM450522 N-[(2-Chloro-4-cyanophenyl)methyl]-2-[6-[4-(oxetane-3-carbonyl)piperazin-1-yl]-4-oxoquinazolin-3-yl]acetamide::US10676446, Example 113

SMILES Clc1cc(ccc1CNC(=O)Cn1cnc2ccc(cc2c1=O)N1CCN(CC1)C(=O)C1COC1)C#N

InChI Key InChIKey=KNQCIKLGKKPVMF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450522   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM450522(N-[(2-Chloro-4-cyanophenyl)methyl]-2-[6-[4-(oxetan...)
Affinity DataIC50:  202nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent