BDBM451025 8-(4-(azetidin-1-ylmethyl)phenyl)-N-((5-fluoro-::US10676479, Example 55

SMILES Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CCC3)cc2)c2cncn12

InChI Key InChIKey=JLQBPFPXOAPVDD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451025   

LigandPNGBDBM451025(8-(4-(azetidin-1-ylmethyl)phenyl)-N-((5-fluoro- | ...)
Affinity DataIC50:  3.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM451025(8-(4-(azetidin-1-ylmethyl)phenyl)-N-((5-fluoro- | ...)
Affinity DataIC50:  37.4nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM451025(8-(4-(azetidin-1-ylmethyl)phenyl)-N-((5-fluoro- | ...)
Affinity DataIC50:  13.7nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent