BDBM451108 US10676485, Example 18
SMILES COc1ccccc1-c1nccc(COc2ccc3OC[C@@H](CN4CCN(C)CC4)Oc4c(Cl)c(C)c(-c5c(C[C@@H]6COCCO6)sc6ncnc(O[C@H](Cc2c3)C(O)=O)c56)c(C)c4Cl)n1
InChI Key InChIKey=METSGICPNWVTFM-XXUJLVSLSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 451108
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataKi: 0.111nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataKi: 0.240nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair