BDBM454845 US10730870, Example 8::US11512083, Example 8

SMILES CC(C)[C@H](N1Cc2cccc(F)c2C1=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C

InChI Key InChIKey=HWJIMIISFDRVKH-VTZPFEBOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 454845   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  3.04E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  619nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  1.33E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  3.04E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  619nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454845(US10730870, Example 8 | US11512083, Example 8)
Affinity DataIC50:  1.33E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent