BDBM455209 US10730874, Compound I-224a::US10730874, Compound I-224b

SMILES COC(=O)C(F)(Cc1cc(cn2cc(Cn3cc(nn3)C(=O)OC(C)(C)C)nc12)C1CC1)C(=O)OC

InChI Key InChIKey=SHJTYGZHVISFOM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455209   

TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455209(US10730874, Compound I-224a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455209(US10730874, Compound I-224a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent