BDBM4572 4-[bis(propan-2-yl)amino]-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide::4-anilinoquinazoline deriv. 10e

SMILES CC(C)N(CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1)C(C)C

InChI Key InChIKey=OZIQEFLVKCIGLR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4572   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4572(4-[bis(propan-2-yl)amino]-N-{4-[(3-bromophenyl)ami...)
Affinity DataIC50:  162nMAssay Description:The HER-2 kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4572(4-[bis(propan-2-yl)amino]-N-{4-[(3-bromophenyl)ami...)
Affinity DataIC50:  97nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed