BDBM4578 4-anilinoquinazoline deriv. 10k::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(4-ethylpiperazin-1-yl)but-2-ynamide

SMILES CCN1CCN(CC#CC(=O)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)CC1

InChI Key InChIKey=JEZCURNCWCILAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4578   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4578(4-anilinoquinazoline deriv. 10k | N-{4-[(3-bromoph...)
Affinity DataIC50:  183nMAssay Description:The HER-2 kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4578(4-anilinoquinazoline deriv. 10k | N-{4-[(3-bromoph...)
Affinity DataIC50:  65nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed