BDBM4587 (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(morpholin-4-yl)but-2-enamide::4-anilinoquinazoline deriv. 16h

SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)\C=C\CN4CCOCC4)cc23)c1

InChI Key InChIKey=OWNBJKMTBSDGLB-GORDUTHDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4587   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4587((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  2.78E+3nMAssay Description:The HER-2 kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4587((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  74nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed