BDBM4596 (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-enamide::4-anilinoquinazoline deriv. 18::6-Substituted 4-Anilinoquinazoline 11

SMILES C\C=C\C(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=JPHUTKJINPEEPQ-DUXPYHPUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4596   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4596((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}bu...)
Affinity DataIC50:  236nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4596((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}bu...)
Affinity DataIC50:  0.550nMpH: 7.4 T: 2°CAssay Description:Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4596((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}bu...)
Affinity DataIC50:  9.13E+4nMAssay Description:The HER-2 kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed