BDBM476982 Inhibitor 5 of SARS-CoV-2 Mpro::US20240092759, Compound 24

SMILES CCCOc1cc(Cl)cc(c1)-c1cc(cn(-c2cccnc2)c1=O)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=GJCBTWHGKCNYAB-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 476982   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476982(Inhibitor 5 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50:  120nMAssay Description:Purified protein is diluted in reaction buffer to 100 nM in an opaque 96-well plate. The protein is incubated with or without compound in DMSO at dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476982(Inhibitor 5 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50:  120nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476982(Inhibitor 5 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476982(Inhibitor 5 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50:  120nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent