BDBM50001497 1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione::CHEMBL417654

SMILES CCCn1c2ncn(C)c2c(=O)n(C)c1=O

InChI Key InChIKey=DHYGGYFMXYRIGJ-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50001497   

TargetAdenosine receptor A2a(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataKi:  9.00E+3nMAssay Description:Compound was evaluated for its ability to antagonise cyclic [3H]-AMP accumulation in [3H]-adenine-labeled guinea pig cerebral cortical slices.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataKi:  1.45E+4nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]-CPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataKi:  2.01E+4nMAssay Description:Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataKi:  2.40E+4nMAssay Description:Ability to inhibit binding of 1 nM [3H]-cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataKi:  3.24E+4nMAssay Description:Inhibitory activity against c-AMP phosphodiesterase in guinea pig tracheal muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001497(1,7-Dimethyl-3-propyl-3,7-dihydro-purine-2,6-dione...)
Affinity DataEC50:  1.06E+4nMAssay Description:Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed