BDBM50002012 (trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethyl-indan-1-yl]-piperazin-1-yl}-ethanol::2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethyl-indan-1-yl]-piperazin-1-yl}-ethanol::CHEMBL1204138::CHEMBL12628::tefludazine

SMILES OCCN1CCN(CC1)C1CC(c2ccc(cc12)C(F)(F)F)c1ccc(F)cc1

InChI Key InChIKey=JSBWGXQXCRYYTG-UHFFFAOYSA-N

Data  5 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50002012   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  8.80nMAssay Description:Ability to displace [3H]haloperidol from rat striatal membranes, in order to measure its intrinsic affinity for the dopamine (DA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  660nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  93nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  7.00E+3nMAssay Description:Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  23nMAssay Description:Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  520nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  10nMAssay Description:Binding affinity against dopamine receptor D2 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed