BDBM50003020 MK-3102::OMARIGLIPTIN::US10155775, Omarigliptin::US10479798, Compound MK3102::US10822319, Compound Omarigliptin
SMILES CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
InChI Key InChIKey=MKMPWKUAHLTIBJ-ISTRZQFTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50003020
Affinity DataKi: 0.800nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of FAP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of PEP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of DPP4 in mouse plasmaMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by MK-499 displacement binding analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of DPP4 (unknown origin) expressed in Sf9 cells using Gly-Pro-AMC substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Screening Method:Name of method: Activity Evaluation of DPP4, Fluorescence.Instrument: Microplate reader, Envision (PerkinElmer, USA).Material: human...More data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Chia Tai Tianqing Pharmaceutical Group
US Patent
Chia Tai Tianqing Pharmaceutical Group
US Patent
Affinity DataIC50: 4.20nMAssay Description:a. White 384-well plate (Perkin Elmer, Catalog No. 607290/99)b. HEPES buffer: using 1M HEPES buffer (Invitrogen, Catalog No. 15630-080) to prepare 50...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant DPP4 incubated for 15 mins using Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of QPP (unknown origin)More data for this Ligand-Target Pair