BDBM50004053 CHEMBL2180006::US10562916, Compound 1::US9834564, Compound 1
SMILES: C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
InChI Key: InChIKey=HMXBVTKCTWFFHC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50004053![]() (CHEMBL2180006 | US10562916, Compound 1 | US9834564...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of PDE10A | J Med Chem 55: 7299-331 (2012) Article DOI: 10.1021/jm3004976 BindingDB Entry DOI: 10.7270/Q2C24XJK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50004053![]() (CHEMBL2180006 | US10562916, Compound 1 | US9834564...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Patents | PDB US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals, Inc. US Patent | Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co... | US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50004053![]() (CHEMBL2180006 | US10562916, Compound 1 | US9834564...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Patents | PDB US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc US Patent | Assay Description The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e... | US Patent US9834564 (2017) BindingDB Entry DOI: 10.7270/Q2FF3VN4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |