BDBM50005019 CHEMBL2408785::US9650336, Example 4
SMILES CO[C@H]1CC[C@]2(Cc3ccc(cc3C22C=C(F)C(N)=N2)-c2cncc(c2)C#CC)CC1
InChI Key InChIKey=FQNMTDWTQKFWEO-OILLYGADSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50005019
Affinity DataIC50: 258nMAssay Description:Inhibition of human BACE1 cloned in HEK293 cells using Eu-CEVNLDAEFK-QSY 7 as substrate preincubated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 258nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells assessed as release of sAPPbeta after 17 hrsMore data for this Ligand-Target Pair