BDBM50005366 1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,6-dione::CHEMBL33722

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cccs1

InChI Key InChIKey=PQZQXCPOCQBALR-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50005366   

TargetAdenosine receptor A1(Rattus norvegicus (rat))
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity against Adenosine A1 receptor in rat cortex by displacement of [3H]-cyclohexyladenosine (CHA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  16nMAssay Description:Binding affinity against adenosine A1 receptor using (R)-N6-(2-[3H]-phenyl-1-methylethyladenosine in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  16nMAssay Description:Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  173nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatum by displacement of [3H]N-ethyladenosine-5''-uronamide(NECA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  210nMAssay Description:Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  381nMAssay Description:Inhibition of binding of [3H]5'-(N-ethylcarbamoyl)-adenosine to adenosine A2 receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  381nMAssay Description:Binding affinity against adenosine A2 receptor using N-[3H]-ethyl adenosine-5-uronamide in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50005366(1,3-Dipropyl-8-thiophen-2-yl-3,7-dihydro-purine-2,...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed