BindingDB PrimarySearch

BDBM50005711 CHEBI:46024::GNF-Pf-1011::TRICHOSTATIN::Trichostatin A::Trichostatin A (TSA)::US10011611, Trichostatin A::US9265734, TSA

SMILES: C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI Key: InChIKey=RTKIYFITIVXBLE-QEQCGCAPSA-N

Data: 26 KI 165 IC50 6 Kd 1 EC50 1 ITC

PDB links: 14 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 198 hits for monomerid = 50005711
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay				Eur J Med Chem 143: 2005-2014 (2018) BindingDB Entry DOI: 10.7270/Q2PK0JT2
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay				Eur J Med Chem 143: 2005-2014 (2018) BindingDB Entry DOI: 10.7270/Q2PK0JT2
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of HDAC10 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay				Eur J Med Chem 143: 2005-2014 (2018) BindingDB Entry DOI: 10.7270/Q2PK0JT2
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 2 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay				Eur J Med Chem 143: 2005-2014 (2018) BindingDB Entry DOI: 10.7270/Q2PK0JT2
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Navarra Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin)				Eur J Med Chem 150: 506-524 (2018) BindingDB Entry DOI: 10.7270/Q2H134MG
University of Navarra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	4.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Navarra Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin)				Eur J Med Chem 150: 506-524 (2018) BindingDB Entry DOI: 10.7270/Q2H134MG
University of Navarra Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Kindai University Curated by ChEMBL					Assay Description Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...				Bioorg Med Chem 26: 1920-1928 (2018) BindingDB Entry DOI: 10.7270/Q2RR21WV
Kindai University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Mus musculus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Kindai University Curated by ChEMBL					Assay Description Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...				Bioorg Med Chem 26: 1920-1928 (2018) BindingDB Entry DOI: 10.7270/Q2RR21WV
Kindai University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC3 using RHKKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC10 using RHKKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	566	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC8 using RHKAcKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC1 using RHKKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC6 using RHKKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC2 using RHKKAc peptide as substrate				J Med Chem 61: 7087-7102 (2018) BindingDB Entry DOI: 10.7270/Q26M39FC
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC3 using RHKK(Ac) as substrate				Eur J Med Chem 150: 667-677 (2018) BindingDB Entry DOI: 10.7270/Q2XW4NGM
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC6 using RHKK(Ac) as substrate				Eur J Med Chem 150: 667-677 (2018) BindingDB Entry DOI: 10.7270/Q2XW4NGM
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC8 using RHKAcKAc as substrate				Eur J Med Chem 150: 667-677 (2018) BindingDB Entry DOI: 10.7270/Q2XW4NGM
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of human HDAC1 using RHKK(Ac) as substrate				Eur J Med Chem 150: 667-677 (2018) BindingDB Entry DOI: 10.7270/Q2XW4NGM
Taipei Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Biomedical Research Curated by ChEMBL					Assay Description Inhibitory activity against histone deacetylase (HDAC) enzyme obtained from H1299 human lung carcinoma cell lysates				J Med Chem 46: 4609-24 (2003) BindingDB Entry DOI: 10.7270/Q2736TP0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Mitsui Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.				J Med Chem 42: 3001-3 (1999) BindingDB Entry DOI: 10.7270/Q22Z1885
Mitsui Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
In2Gen Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells				J Med Chem 46: 5745-51 (2003) BindingDB Entry DOI: 10.7270/Q2639SGQ
In2Gen Co. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sirtuin-6 (SIRT6) (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a
University of Bayreuth Curated by ChEMBL					Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...				J Med Chem 61: 10922-10928 (2018) BindingDB Entry DOI: 10.7270/Q2GQ71GJ
University of Bayreuth Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sirtuin-6 (SIRT6) (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a
University of Bayreuth Curated by ChEMBL					Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...				J Med Chem 61: 10922-10928 (2018) BindingDB Entry DOI: 10.7270/Q2GQ71GJ
University of Bayreuth Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sirtuin-6 (SIRT6) (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	n/a	2.27E+5	n/a	n/a	n/a	n/a	n/a
University of Bayreuth Curated by ChEMBL					Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins by fluorescence-based SDS...				J Med Chem 61: 10922-10928 (2018) BindingDB Entry DOI: 10.7270/Q2GQ71GJ
University of Bayreuth Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sirtuin-6 (SIRT6) (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	n/a	4.45E+5	n/a	n/a	n/a	n/a	n/a
University of Bayreuth Curated by ChEMBL					Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of NAM by flu...				J Med Chem 61: 10922-10928 (2018) BindingDB Entry DOI: 10.7270/Q2GQ71GJ
University of Bayreuth Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC6 using RHKKAcAMC as substrate by fluorescence assay				Eur J Med Chem 152: 329-357 (2018) BindingDB Entry DOI: 10.7270/Q2M90CCS
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required to inhibit the partially purified HDAC enzyme by 50% obtained from H1299 cell lysate				J Med Chem 45: 753-7 (2002) BindingDB Entry DOI: 10.7270/Q2T156D5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required to inhibit human Histone deacetylase (HDAC) enzyme by 50%				J Med Chem 45: 753-7 (2002) BindingDB Entry DOI: 10.7270/Q2T156D5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Mashhad University of Medical Sciences Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay				J Nat Prod 78: 2867-79 (2015) BindingDB Entry DOI: 10.7270/Q2PG1VR7
Mashhad University of Medical Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 3a				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 5a				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 3b				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 12a				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 5b				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Hdac5 protein (Rattus norvegicus)	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibition concentration required to inhibit rat liver histone deacetylase (HDAC) in the presence of compound 5e as a substrate				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5a				J Med Chem 47: 5235-43 (2004) BindingDB Entry DOI: 10.7270/Q2086839
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA				Bioorg Med Chem Lett 26: 154-9 (2016) BindingDB Entry DOI: 10.7270/Q2BK1GCP
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology Curated by ChEMBL					Assay Description Inhibition of human HDAC in HeLa cells by flour de lys assay				Bioorg Med Chem 16: 4839-53 (2008) BindingDB Entry DOI: 10.7270/Q2862K6N
Georgia Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 4 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC4 using p53 residues 379-382 (RHKKAc) as substrate				Bioorg Med Chem 21: 5339-54 (2013) BindingDB Entry DOI: 10.7270/Q2N300XN
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC6 using p53 residues 379-382 (RHKKAc) as substrate				Bioorg Med Chem 21: 5339-54 (2013) BindingDB Entry DOI: 10.7270/Q2N300XN
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC1 using p53 residues 379-382 (RHKKAc) as substrate				Bioorg Med Chem 21: 5339-54 (2013) BindingDB Entry DOI: 10.7270/Q2N300XN
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Pennsylvania State Hershey College of Medicine Curated by ChEMBL					Assay Description Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay				Bioorg Med Chem Lett 20: 2044-7 (2010) BindingDB Entry DOI: 10.7270/Q2DF6V2B
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of HDAC8 (unknown origin) after 30 mins by fluorometric analysis				Bioorg Med Chem 21: 4201-9 (2013) BindingDB Entry DOI: 10.7270/Q2S46VXV
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 2 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 30 mins by fluorometric analysis				Bioorg Med Chem 21: 4201-9 (2013) BindingDB Entry DOI: 10.7270/Q2S46VXV
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 30 mins by fluorometric analysis				Bioorg Med Chem 21: 4201-9 (2013) BindingDB Entry DOI: 10.7270/Q2S46VXV
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Nankai University Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay				Eur J Med Chem 46: 3190-200 (2011) BindingDB Entry DOI: 10.7270/Q2PV6P6P
Nankai University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of human HDAC after 30 mins				Bioorg Med Chem 18: 8457-62 (2010) BindingDB Entry DOI: 10.7270/Q2ZS30DR
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay				Bioorg Med Chem 18: 415-25 (2010) BindingDB Entry DOI: 10.7270/Q2RV0RJB
Georgia Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50005711
Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Histone deacetylase 8 (HDAC8) (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...)	GoogleScholar PDB	DrugBank PC cid PC sid PDB		-8.60	0.0179	-8.80	6.53	7.5	-248
North Dakota State University		GoogleScholar PDB	DrugBank PC cid PC sid PDB		Biochemistry 53: 7445-58 (2014)