BDBM50006821 4-Methyl-N-[3-(quinolin-2-ylmethoxy)-benzoyl]-benzenesulfonamide::CHEMBL310833

SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1cccc(OCc2ccc3ccccc3n2)c1

InChI Key InChIKey=RQFQHHZDINZMGC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50006821   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006821(4-Methyl-N-[3-(quinolin-2-ylmethoxy)-benzoyl]-benz...)
Affinity DataIC50:  6.20E+3nMAssay Description:Concentration that produces 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006821(4-Methyl-N-[3-(quinolin-2-ylmethoxy)-benzoyl]-benz...)
Affinity DataIC50:  1.34E+4nMAssay Description:Concentration that produces 50% inhibition of A-23187-stimulated radiolabeled 5-HETE and TXB2 synthesis by Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006821(4-Methyl-N-[3-(quinolin-2-ylmethoxy)-benzoyl]-benz...)
Affinity DataIC50:  3.90E+3nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed