BDBM50007100 CHEMBL3237569::US10112928, Compound I-4

SMILES Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1

InChI Key InChIKey=VZTTZPLGSADLLI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007100   

TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50007100(CHEMBL3237569 | US10112928, Compound I-4)
Affinity DataIC50:  671nMpH: 7.5Assay Description:SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007100(CHEMBL3237569 | US10112928, Compound I-4)
Affinity DataIC50:  631nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed