BDBM50008746 CHEMBL3236343
SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
InChI Key InChIKey=PYIJFQHNPPKBFX-UHFFFAOYSA-N
Data 24 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50008746
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human Nav1.8 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.6 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.8 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.8 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair