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BDBM50009860 2-(6-Methoxy-naphthalen-2-yl)-propionic acid::2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen)::2-(6-methoxy-2-naphthyl)propanoic acid::2-(6-methoxynaphthalen-2-yl)propanoic acid::CHEMBL154::Naproxen::Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid

SMILES: COc1ccc2cc(ccc2c1)C(C)C(O)=O

InChI Key: InChIKey=CMWTZPSULFXXJA-UHFFFAOYSA-N

Data: 5 KI  7 IC50

PDB links: 10 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50009860   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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PubMed
9.30E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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>1.00E+4n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase


(Homo sapiens (human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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>1.00E+4n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)

More data for this
Ligand-Target Pair
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Department of Horticulture and National Food Safety and Toxicology Center

Curated by ChEMBL


Assay Description
Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin


J Nat Prod 62: 294-6 (1999)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate


J Med Chem 40: 819-24 (1997)

More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition activity against recombinant human Prostaglandin G/H synthase 2


J Med Chem 40: 819-24 (1997)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition activity against recombinant human Prostaglandin G/H synthase 1


J Med Chem 40: 819-24 (1997)

More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 2.43E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of human umbilical cord endothelial cells(ECV-304 cell line) Prostaglandin G/H synthase 2 at 10 microM


Bioorg Med Chem Lett 6: 2281-2282 (1996)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 350n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 microM


Bioorg Med Chem Lett 6: 2281-2282 (1996)

More data for this
Ligand-Target Pair