Found 16 hits for monomerid = 50010981 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| 189 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| 1.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description TNF-alpha production in PBMC by ELISA method |
J Med Chem 39: 2-9 (1996)
Article DOI: 10.1021/jm940845j BindingDB Entry DOI: 10.7270/Q29S1Q46 |
More data for this Ligand-Target Pair | |
Phosphodiesterase 1
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibitory activity against PDE1 from cerebral cortex |
J Med Chem 40: 3248-53 (1997)
BindingDB Entry DOI: 10.7270/Q2K93B7D |
More data for this Ligand-Target Pair | |
Phosphodiesterase 1
(Bos taurus-BOVINE) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| n/a | n/a | 9.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Neurochimie du CNRS
Curated by ChEMBL
| Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu... |
J Med Chem 32: 1450-7 (1989)
Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Neurochimie du CNRS
Curated by ChEMBL
| Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE. |
J Med Chem 32: 1450-7 (1989)
Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Phosphodiesterase 2A
(Rattus norvegicus) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
Article DOI: 10.1021/jm00352a019 BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this Ligand-Target Pair | |
Phosphodiesterase 1
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lung |
J Med Chem 28: 537-45 (1985)
Article DOI: 10.1021/jm50001a001 BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE) |
J Med Chem 34: 291-8 (1991)
Article DOI: 10.1021/jm00105a045 BindingDB Entry DOI: 10.7270/Q2NV9MG8 |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibitory activity against Phosphodiesterase 3 from heart. |
J Med Chem 40: 3248-53 (1997)
BindingDB Entry DOI: 10.7270/Q2K93B7D |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibitory activity against Phosphodiesterase 4 from heart. |
J Med Chem 40: 3248-53 (1997)
BindingDB Entry DOI: 10.7270/Q2K93B7D |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Glasgow
Curated by ChEMBL
| Assay Description Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay |
J Med Chem 54: 3331-47 (2011)
Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Phosphodiesterase 5A
(Bos taurus) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Neurochimie du CNRS
Curated by ChEMBL
| Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE. |
J Med Chem 32: 1450-7 (1989)
Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB MMDB
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| n/a | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a |
University of Glasgow
Curated by ChEMBL
| Assay Description Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci |
J Med Chem 54: 3331-47 (2011)
Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
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| n/a | n/a | 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lung |
J Med Chem 28: 537-45 (1985)
Article DOI: 10.1021/jm50001a001 BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |