BindingDB PrimarySearch

BDBM50010981 (Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one::4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one::4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one(Ro 20-1724)::4-(3-Butyl-4-methoxy-benzyl)-imidazolidin-2-one::CHEMBL18701::RO 20-1724::Ro-20-1724

SMILES: CCCCOc1cc(CC2CNC(=O)N2)ccc1OC

InChI Key: InChIKey=PDMUULPVBYQBBK-UHFFFAOYSA-N

Data: 3 KI 9 IC50 1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50010981
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 4 (RAT)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	189	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Curated by PDSP K_i Database									J Pharmacol Exp Ther 305: 565-72 (2003) Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG
University of Tennessee Curated by PDSP K_i Database					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.93E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
Glaxo Wellcome Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (RAT)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Curated by PDSP K_i Database									J Pharmacol Exp Ther 305: 565-72 (2003) Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG
University of Tennessee Curated by PDSP K_i Database					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE)				J Med Chem 34: 291-8 (1991) Article DOI: 10.1021/jm00105a045 BindingDB Entry DOI: 10.7270/Q2NV9MG8
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lung				J Med Chem 28: 537-45 (1985) Article DOI: 10.1021/jm50001a001 BindingDB Entry DOI: 10.7270/Q2N58MXT
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Bos taurus-BOVINE)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	9.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...				J Med Chem 32: 1450-7 (1989) Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 2A (Rattus norvegicus)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of rat brain particulate cGMP phosphodiesterase				J Med Chem 25: 1192-8 (1983) Article DOI: 10.1021/jm00352a019 BindingDB Entry DOI: 10.7270/Q21G0NFF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lung				J Med Chem 28: 537-45 (1985) Article DOI: 10.1021/jm50001a001 BindingDB Entry DOI: 10.7270/Q2N58MXT
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Glasgow Curated by ChEMBL					Assay Description Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay				J Med Chem 54: 3331-47 (2011) Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75
University of Glasgow Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 5A (Bos taurus)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) Article DOI: 10.1021/jm00127a009 BindingDB Entry DOI: 10.7270/Q2DN441H
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a
University of Glasgow Curated by ChEMBL					Assay Description Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci				J Med Chem 54: 3331-47 (2011) Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75
University of Glasgow Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description TNF-alpha production in PBMC by ELISA method				J Med Chem 39: 2-9 (1996) Article DOI: 10.1021/jm940845j BindingDB Entry DOI: 10.7270/Q29S1Q46
University of California Curated by ChEMBL					More data for this Ligand-Target Pair