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BDBM50011177 CHEMBL3260315

SMILES: Fc1ccc(CN(C(=O)CN2CCC=CC2)c2ncc(s2)C(=O)NCCCn2ccnc2)cc1

InChI Key: InChIKey=GTUHHIAWNJUOAD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011177   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50011177
PNG
(CHEMBL3260315)
Show SMILES Fc1ccc(CN(C(=O)CN2CCC=CC2)c2ncc(s2)C(=O)NCCCn2ccnc2)cc1
Show InChI InChI=1S/C24H27FN6O2S/c25-20-7-5-19(6-8-20)16-31(22(32)17-29-11-2-1-3-12-29)24-28-15-21(34-24)23(33)27-9-4-13-30-14-10-26-18-30/h1-2,5-8,10,14-15,18H,3-4,9,11-13,16-17H2,(H,27,33)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.632n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminally His-tagged NAMPT by TR-FRET assay in presence of PRPP


ACS Med Chem Lett 5: 277-277 (2014)


Article DOI: 10.1021/ml500046t
BindingDB Entry DOI: 10.7270/Q25X2BF6
More data for this
Ligand-Target Pair