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BDBM50015094 CHEMBL152665::N-Hydroxy-2-phenyl-acetamide::N-hydroxy-2-phenylacetamide::Phenylacetohydroxamic acid

SMILES: ONC(=O)Cc1ccccc1

InChI Key: InChIKey=FPOQLQZHRCEVOT-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50015094   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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PubMed
n/an/a 3.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)


J Med Chem 33: 992-8 (1990)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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PubMed
n/an/a 3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against RBL-1 5-LO


J Med Chem 30: 574-80 (1987)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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Article
PubMed
n/an/a>3.33E+4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
MMDB

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PubMed
n/an/a 158n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)


J Med Chem 33: 992-8 (1990)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
MMDB

NCI pathway
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KEGG

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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/a>3.33E+4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)

More data for this
Ligand-Target Pair