BDBM50015382 CHEMBL3264645

SMILES Cc1ccc(cc1)-c1nn(Cc2cccc(c2)C(F)(F)F)cc1C(=O)Nc1ccc(C)c(c1)S(=O)(=O)N1CCOCC1

InChI Key InChIKey=MKJQGOXHYLZPAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015382   

TargetBile acid receptor(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50015382(CHEMBL3264645)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human GST-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50015382(CHEMBL3264645)
Affinity DataIC50:  515nMAssay Description:Inhibition of GW4064-induced transactivation of FXR (unknown origin) expressed in HEK293T cells after 16 hrs by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed