BDBM50016777 ((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium::(8-Hydroxyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine::(R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol::7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol::7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ((R)-OH-DPAT)::7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol(8-OH-DPAT)::CHEMBL26998::R-(+)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol

SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1

InChI Key InChIKey=ASXGJMSKWNBENU-CQSZACIVSA-N

Data  21 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50016777   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor in bovine hippocampal preparation using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Mus musculus (Mouse))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for inhibiting the binding of [3H]- 8-OH-DPAT to 5-HT1A-receptor from cerebral cortex membranes of ratMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]-8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  3.10nMAssay Description:In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT (agonist) as radioligand (sc)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cortex membranes after 15 mins by liquid scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]-5-carboxamidotryptamine from human 5-HT1A receptor expressed in HEK293T cell membranes incubated for 90 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  8.81nMAssay Description:Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  46nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  90nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 by using [3H]U-86170 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  164nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  179nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 by using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi: >413nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 by using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  638nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of G£teborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  819nMAssay Description:Binding affinity of the compound was measured on cloned Human D2A Receptor which is labeled by [3H]-RacloprideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  826nMAssay Description:Displacement of [3H]-spiperone from dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataIC50:  4.80nMAssay Description:Concentration of compound required to inhibit cortical 5-hydroxytryptamine 1A receptor binding sites in rat brain was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed