BDBM50019277 2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-one (6)::CHEMBL3289119

SMILES Oc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=FXCFQTZURPSAGN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50019277   

TargetThymidine phosphorylase(Escherichia coli (Enterobacteria))
University Of Karachi

LigandPNGBDBM50019277(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Affinity DataIC50:  5.95E+4nMpH: 7.0Assay Description:TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 µ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019277(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Escherichia coli)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50019277(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Affinity DataIC50:  5.95E+4nMAssay Description:Inhibition of recombinant Escherichia coli thymidine phosphorylase using thymidine as substrate measured after 10 mins at 30 degC by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019277(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed