BindingDB logo
myBDB logout

BDBM50021437 5-Ethyl-5-phenylbarbituric acid::5-Phenyl-5-ethylbarbituric acid::5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione::5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione::CHEMBL40::Phenobarbital::Phenobarbitol::Phenobarbitone::Phenobarbituric Acid::Phenylaethylbarbitursaeure::Phenylethylbarbiturate::Phenylethylbarbituric Acid::Phenylethylbarbitursaeure

SMILES: CCC1(C(=O)NC(=O)NC1=O)c1ccccc1

InChI Key: InChIKey=DDBREPKUVSBGFI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50021437   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50021437
PNG
(5-Ethyl-5-phenylbarbituric acid | 5-Phenyl-5-ethyl...)
Show SMILES CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
Show InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.02E+6n/an/an/an/an/an/a



TCG Lifesciences Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Eur J Med Chem 46: 618-30 (2011)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50021437
PNG
(5-Ethyl-5-phenylbarbituric acid | 5-Phenyl-5-ethyl...)
Show SMILES CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
Show InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.02E+6n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human ERG channel in HEK293 cells by voltage-clamp method


Eur J Med Chem 43: 2479-88 (2008)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50021437
PNG
(5-Ethyl-5-phenylbarbituric acid | 5-Phenyl-5-ethyl...)
Show SMILES CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
Show InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+6n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against IKr potassium channel


Bioorg Med Chem Lett 14: 4771-7 (2004)

More data for this
Ligand-Target Pair
Sodium channel protein type I I alpha subunit


(Homo sapiens (Human))
BDBM50021437
PNG
(5-Ethyl-5-phenylbarbituric acid | 5-Phenyl-5-ethyl...)
Show SMILES CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
Show InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channel


J Med Chem 29: 1512-6 (1986)

More data for this
Ligand-Target Pair