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BDBM50026777 2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol::2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol (methoxamine)::2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol(Methoxamine)::CHEMBL524::METHOXAMINE::Vasoxyl

SMILES: COc1ccc(OC)c(c1)C(O)C(C)N

InChI Key: InChIKey=WJAJPNHVVFWKKL-UHFFFAOYSA-N

Data: 15 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50026777   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
940n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Mol Pharmacol 13: 454-73 (1977)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
1.61E+3n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Biol Chem 266: 6365-9 (1991)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Biol Chem 266: 6365-9 (1991)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



National Children's Medical Research Center

Curated by PDSP Ki Database




Eur J Pharmacol 268: 399-407 (1994)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



National Children's Medical Research Center, Tokyo

Curated by PDSP Ki Database




Biochem Biophys Res Commun 195: 902-9 (1993)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Biol Chem 266: 6365-9 (1991)

More data for this
Ligand-Target Pair
adrenergic Alpha2


(RAT)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



University of California

Curated by PDSP Ki Database




J Pharmacol Exp Ther 241: 1092-8 (1987)

More data for this
Ligand-Target Pair
adrenergic Alpha2


(RAT)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of California

Curated by PDSP Ki Database




J Pharmacol Exp Ther 241: 1092-8 (1987)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
adrenergic Alpha1


(BOVINE)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
adrenergic Alpha1


(HAMSTER)
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 272: 134-42 (1995)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
1.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Mol Pharmacol 13: 454-73 (1977)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026777
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N
Show InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
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PubMed
n/an/an/an/a 720n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor agonist activity in rabbit ear artery


J Med Chem 24: 1432-7 (1982)

More data for this
Ligand-Target Pair