BDBM50027475 (E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one (3)::2,2'',4''-Trihydroxychalcone::CHEMBL148472

SMILES Oc1ccc(C(=O)\C=C\c2ccccc2O)c(O)c1

InChI Key InChIKey=MACMAADVRVVHBD-VMPITWQZSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50027475   

TargetBeta-secretase 1(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataIC50:  2.45E+3nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)TBA
LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataIC50:  380nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrase(Human immunodeficiency virus 1)
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataIC50:  5.30E+4nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50027475((E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-...)
Affinity DataIC50:  5.68E+4nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed