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BDBM50027796 2-(Sulfanilylamino)thiazole::2-(p-Aminobenzenesulfonamido)thiazole::2-(p-Aminobenzenesulphonamido)thiazole::2-Sulfanilamidothiazol::2-Sulfanilamidothiazole::2-Sulfonamidothiazole::4-Amino-N-2-thiazolylbenzenesulfonamide::4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide::CHEMBL437::N(1)-2-Thiazolylsulfanilamide::Sulfanilamidothiazole::Sulfathiazole::Sulphathiazole::cid_5340

SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1nccs1

InChI Key: InChIKey=JNMRHUJNCSQMMB-UHFFFAOYSA-N

Data: 5 IC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50027796   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
exonuclease V (RecBCD complex), alpha chain


(Escherichia coli str. K-12 substr. MG1655)
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PCBioAssay
n/an/a 7.59E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay




PubChem Bioassay (2013)

More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
Reactome pathway
KEGG

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CHEMBL
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KEGG
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PC sid
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PubMed
n/an/a 6.90E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)

More data for this
Ligand-Target Pair
Bacterial dihydropteroate synthase


(Escherichia coli (strain K12))
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
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PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of dihydropteroate synthase from Escherichia coli.


J Med Chem 28: 1870-4 (1986)

More data for this
Ligand-Target Pair
EDNRA


()
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
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Article
PubMed
n/an/a 6.90E+4n/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against Endothelin A receptor


J Med Chem 47: 1303-14 (2004)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
PDB

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PubMed
n/an/a 4.30E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair