BDBM50028980 8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine::8-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine::CHEMBL7828::Isoloxapine

SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Oc2ccccc12

InChI Key InChIKey=AWHNHDGHHNGACT-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50028980   

Target5-hydroxytryptamine receptor 2A(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  11nMAssay Description:Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  19nMAssay Description:Affinity of the compound was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C recept...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  23nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  39nMAssay Description:Affinity was evaluated by inhibition of [3H]-GR-65,630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  150nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  150nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataIC50:  49nMAssay Description:Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50028980(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataIC50:  2.48E+3nMAssay Description:Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nucleiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed