BDBM50030791 CHEMBL3342402

SMILES Cc1ccc(cc1)-c1csc2nnc(SCC(=O)Nc3ccc4OCOc4c3)n12

InChI Key InChIKey=XYXNYQAJSYUYNZ-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50030791   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1 assessed as reduction in convertion of N-formylkynurenine to kynurenine incubated for 30 minsMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Colorado College

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50: >6.25E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Colorado College

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human IDO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1 by Bridge-IT Tryptophan fluorescence assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Colorado College

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50: >2.50E+5nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1 using Trp as substrate after 90 mins by Bridge-IT tryptophan fluorescence assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant IDO1 expressed in Escherichia coli BL21 using tryptophan as substrate after 90 mins by fluores...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human IDO1 incubated for 60 mins in presence of L-tryptophan by HPLC analysisMore data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Colorado College

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50: >6.25E+4nMAssay Description:Inhibition of human TDO using Trp as substrate after 90 mins by Bridge-IT tryptophan fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed