BDBM50036210 (2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid::CHEMBL118715

SMILES O[C@H](C(O)=O)[C@@](O)(CC(O)=O)C(O)=O

InChI Key InChIKey=ZMJBYMUCKBYSCP-CVYQJGLWSA-N

Data  5 KI  1 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50036210   

TargetATP-citrate synthase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Reversible binding potential for rat ATP-Citrate Lyase as carbon-carbon bond cleavage activity in citrate substrateMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  3.00E+5nMAssay Description:Competitive inhibition of human liver ACLY using varying levels of citrate as substrateMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant ATP-citrate lyaseMore data for this Ligand-Target Pair