BDBM50036696 2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl)-benzylidene]-malononitrile::CHEMBL334032

SMILES [#6]-[#8]-c1cc(\[#6]=[#6](/C#N)C#N)cc(-[#6]S(=O)(=O)c2ccc(-[#6])cc2)c1-[#8]

InChI Key InChIKey=OHHGMKTWWGWUJB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50036696   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibitiory concentration against EGF receptor by autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibitiory concentration against EGF receptor by autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibitiory concentration against EGF receptor by polyGAT phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed