BDBM50037076 CHEMBL3355737

SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(cc(Nc2cc([nH]n2)C2CCCC2)n1)S(=O)(=O)c1ccccc1

InChI Key

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50037076   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Evotec

Curated by ChEMBL

LigandBDBM50037076(CHEMBL3355737)Copy SMILES

Affinity DataKi:  0.170nMAssay Description:Inhibition of GST-tagged full-length ITK (unknown origin) using Ac-EFPIYDFLPAKKK-NH2 as substrate after 35 mins by LC/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1(Homo sapiens (Human))
Evotec

Curated by ChEMBL

LigandBDBM50037076(CHEMBL3355737)Copy SMILES

Affinity DataIC50:  180nMAssay Description:Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 minsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI