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BDBM50039729 3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dimethylbenzo[d]isoxazole::3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-5,6-dimethyl-benzo[d]isoxazole::CHEMBL91291

SMILES: Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C

InChI Key: InChIKey=NCERWLVJTKFIHR-UHFFFAOYSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50039729   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases


(Homo sapiens (Human))
BDBM50039729
PNG
(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dimethylbe...)
Show SMILES Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C
Show InChI InChI=1S/C23H28N2O/c1-17-14-21-22(24-26-23(21)15-18(17)2)9-8-19-10-12-25(13-11-19)16-20-6-4-3-5-7-20/h3-7,14-15,19H,8-13,16H2,1-2H3
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Article
PubMed
n/an/a 5.75n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro (UFRJ)

Curated by ChEMBL


Assay Description
Inhibition of human acetylcholinesterase


Eur J Med Chem 46: 39-51 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.009
BindingDB Entry DOI: 10.7270/Q2SX6FG0
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50039729
PNG
(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dimethylbe...)
Show SMILES Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C
Show InChI InChI=1S/C23H28N2O/c1-17-14-21-22(24-26-23(21)15-18(17)2)9-8-19-10-12-25(13-11-19)16-20-6-4-3-5-7-20/h3-7,14-15,19H,8-13,16H2,1-2H3
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Article
PubMed
n/an/a 5.79n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50039729
PNG
(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dimethylbe...)
Show SMILES Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C
Show InChI InChI=1S/C23H28N2O/c1-17-14-21-22(24-26-23(21)15-18(17)2)9-8-19-10-12-25(13-11-19)16-20-6-4-3-5-7-20/h3-7,14-15,19H,8-13,16H2,1-2H3
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PubMed
n/an/a 5.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of AChE


Eur J Med Chem 45: 1167-72 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.038
BindingDB Entry DOI: 10.7270/Q25H7GFM
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50039729
PNG
(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dimethylbe...)
Show SMILES Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C
Show InChI InChI=1S/C23H28N2O/c1-17-14-21-22(24-26-23(21)15-18(17)2)9-8-19-10-12-25(13-11-19)16-20-6-4-3-5-7-20/h3-7,14-15,19H,8-13,16H2,1-2H3
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Article
PubMed
n/an/a 5.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytes


J Med Chem 37: 2721-34 (1994)


Article DOI: 10.1021/jm00043a012
BindingDB Entry DOI: 10.7270/Q2VT1R4X
More data for this
Ligand-Target Pair