BDBM50040914 5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-1,3-dione::CHEMBL8095

SMILES COc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccccc2)cc1

InChI Key InChIKey=LESFPZSUPOHBIP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040914   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50:  6.40E+4nMAssay Description:Inhibitory activity against c-src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against v-abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040914(5-(4-Methoxy-phenylamino)-6-phenylamino-isoindole-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibitory activity was determined against protein kinase A (PKA) of rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed