BDBM50048338 CHEMBL3315060::US9593113, Example 24

SMILES COc1ccc(CNC(=O)NC(=O)C(C)(C)[C@@H]2c3ccc(nc3Oc3c(F)cccc23)-c2ccc(cc2)C(=O)N2CCOCC2)cc1

InChI Key InChIKey=KSINXTGJLYCZIP-PMERELPUSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048338   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataKi:  7.40nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataKi:  7.45nMAssay Description:Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProgesterone receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataKi:  623nMAssay Description:Binding affinity to progesterone receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataEC50:  1.05E+4nMAssay Description:Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataEC50:  149nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50048338(CHEMBL3315060 | US9593113, Example 24)
Affinity DataEC50:  244nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed