BDBM50049309 CHEMBL348976::N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)-amino]-methyl}-2-(1H-indol-3-yl)-ethyl]-2-(4-cyclohexyl-piperazin-1-yl)-acetamide

SMILES COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(CC1)C1CCCCC1)C(C)=O

InChI Key InChIKey=HCKQHXNWJMHBJT-MUUNZHRXSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50049309   

TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049309(CHEMBL348976 | N-[(R)-1-{[Acetyl-(2-methoxy-benzyl...)
Affinity DataIC50:  0.180nMAssay Description:Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049309(CHEMBL348976 | N-[(R)-1-{[Acetyl-(2-methoxy-benzyl...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049309(CHEMBL348976 | N-[(R)-1-{[Acetyl-(2-methoxy-benzyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity of the compound against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed