BDBM50052176 (2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-isoxazol-5-yl)-8-aza-bicyclo[3.2.1]octane::CHEMBL92610

SMILES CN1[C@@H]2CCC1[C@H](C(C2)c1ccc(Cl)cc1)c1cc(no1)-c1ccccc1

InChI Key InChIKey=ZGCYMNJHHKQEGA-SYMYNJCGSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50052176   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50052176((2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-i...)
Affinity DataKi:  2.10nMAssay Description:Ability to inhibit [3H]dopamine uptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50052176((2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-i...)
Affinity DataIC50:  2.42E+3nMAssay Description:Binding affinity against serotonin transporter using [3H]paroxetine in rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50052176((2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-i...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity against Dopamine transporter using [3H]WIN-35 428 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50052176((2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-i...)
Affinity DataIC50:  504nMAssay Description:Binding affinity against Norepinephrine transporter using [3H]nisoxetine in midbrain of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed